Folate deficiency is characterized by megaloblastic anemia and low serum folate levels. Most patients with folate deficiency have inadequate intake. Lactate dehydrogenase (LDH) and indirect bilirubin typically are elevated, reflecting ineffective erythropoiesis and premature destruction of RBCs.
	RBC folic acid and serum vitamin B12 levels should be measured. RBC folate is a more accurate indicator of body folate stores than is serum folate, particularly if measured after folate therapy.